Of all the Anadrol side effects, liver toxicity (hepatotoxicity) is of the greatest concern. Most oral steroids are alkylated, which means they’ve been specially designed in such a way that they will still be useful to your body once they’ve been processed by your liver. To reduce risk, it’s vital to use supplements like milk thistle, which serve as protections against potential damage; and drink plenty of water. It’s also important to use the lowest possible dose that provides you with benefits, and to adjust your cycle length based on your dose.
In general it has been found that oral steroids are more likely to prove detrimental to cardiovascular health than injectable forms of non C-17 alkyl steroids. In this regard it is important to point out that estrogen is actually known to have a positive effect on cholesterol levels, enhancing HDL levels, and keeping LDL levels under control. It is when aromatase inhibitors in ancillary compounds come into play during the steroid cycles that the individual is at risk of cardio-vascular diseases owing to estrogen levels being subdued. Further, it has been seen that when the individual is committed to a healthy diet that supports desired cholesterol levels during the steroid cycle , the risk of cardiovascular disease arising from steroid use can be kept under control.