Primobolan side effects include that of cardiovascular strain and negative cholesterol changes, which is a side effect shared among all anabolic steroids. This involves the reduction of HDL (the good cholesterol) and increases of LDL (the bad cholesterol). The result of such changes is an increased risk of arteriosclerosis, and the degree to which these changes occur for the worse are usually dose-dependent (with higher doses increasing the negative changes and the risks). Other factors that affect these negative cholesterol changes are: duration of use, and route of administration. In terms of the route of administration, oral anabolic steroids are known as being the worst for their negative impacts on cholesterol in comparison to injectable anabolic steroids. This is where oral anabolic steroids hold a negative reputation for exhibiting a far worse negative impact on cholesterol in comparison to injectable anabolic steroids. This is due to the fact that the liver is essentially the body’s cholesterol processing and production center, and increased hepatotoxicity as a result of oral anabolic steroid use is associated with negative cholesterol changes.