Oxymetholone is as mentioned very hepatic and liver enzymes will necessarily increase dramatically with its use. For this reason most Oxymetholone use will generally need to be kept at 6 weeks max with many never needing to go beyond 4 weeks of total use. While this is a very short lived duration its important to note, Oxymetholone appears to be one of the few steroids that really diminishes after use is extended; meaning, even if you went past the 6 week mark you probably wouldnt get much out of it other than damaging your liver. It is comforting to note, while it is toxic to the liver, when used responsibly any toxic effect will be of little concern as the liver will quickly return to normal once use is discontinued. It is important to note, as this steroid is hepatic it does not carry near the level of hepatotoxicity as many over the counter medications and regular alcohol consumption.