Oxymetholone metabolites

For example, anabolic steroids such as Testosterone have a tendency to promote water retention through their ability to be aromatized into Estrogen via the aromatase enzyme. While such an effect might not be a concern for a strength athlete or a powerlifter (such an effect might even be beneficial or desired in such sports), this is not a desired effect for athletes involved in sports that involve speed and swiftness, such as sprinting. Instead, a sprinter, for example, would more likely opt for an anabolic steroid such as Stanozolol ( Winstrol ) or Oxandrolone ( Anavar ), which are two anabolic steroids unable to convert into Estrogen and therefore the issue of water retention, and therefore the issue of added weight that would slow the athlete down is avoided. Many athletes may also elect to ‘stack’ anabolic steroids in a given cycle (stacking refers to the practice of combining more than one anabolic steroid in a cycle). In the case of cycle stacks, an individual might be able to increase the synergy and synergistic effects between the anabolic steroids to create a highly anabolic environment or to create a stack that might assist the user in favoring certain particular athletic or physique goals. These are some of the major reasons as to why the development of different types of steroids has been done.

Tibolone, also known as 7α-methylnoretynodrel, as well as 7α-methyl-17α-ethynyl-19-nor-δ 5(10) -testosterone or as 7α-methyl-17α-ethynylestr-5(10)-en-17β-ol-3-one, is a synthetic estrane steroid and a derivative of testosterone and 19-nortestosterone . [7] [1] It is more specifically a derivative of norethisterone (17α-ethynyl-19-nortestosterone) and is a member of the estrane subgroup of the 19-nortestosterone family of progestins. [1] [51] [52] [15] Tibolone is the 7α-methyl derivative of the progestin noretynodrel (17α-ethynyl-δ 5(10) -19-nortestosterone). [1] Other steroids related to tibolone include the progestin norgesterone (17α-vinyl-δ 5(10) -19-nortestosterone) and the anabolic steroids trestolone (7α-methyl-19-nortestosterone) and mibolerone (7α,17α-dimethyl-19-nortestosterone). [7]

It is interesting to note that oxymetholone does exhibit some tendency to convert to dihydrotestosterone in the body, although this does not occur via the 5-alpha reductase enzyme. Oxymetholone is already a dihydrotestosterone-based steroid, so no such alteration can take place. Aside from the added c-17 alpha alkylation (discussed below), oxymetholone differs from DHT only by the addition of a 2-hydroxymethylene group. This grouping can be removed metabolically, reducing oxymetholone to the potent androgen 17alpha-methyl dihydrotestosterone (mestanolone). 387 There is little doubt that this biotransformation contributes at least on some level to the androgenic nature of this steroid. Note that since 5-alpha reductase is not involved, the relative androgenicity of oxymetholone is not affected by the concurrent use of finasteride or dutasteride.

There is limited information available on the pharmacokinetics of oxymetholone. [4] It appears to be well-absorbed with oral administration . [4] Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT. [1] The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation . [4] [2] The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone. [3] The elimination half-life of oxymetholone is unknown. [2] Oxymetholone and its metabolites are eliminated in the urine . [1] [2]

Oxymetholone metabolites

oxymetholone metabolites

There is limited information available on the pharmacokinetics of oxymetholone. [4] It appears to be well-absorbed with oral administration . [4] Oxymetholone has very low affinity for human serum sex hormone-binding globulin (SHBG), less than 5% of that of testosterone and less than 1% of that of DHT. [1] The drug is metabolized in the liver by oxidation at the C2 position, reduction at the C3 position, hydroxylation at the C17 position, and conjugation . [4] [2] The C2 hydroxymethylene group of oxymetholone can be cleaved to form mestanolone (17α-methyl-DHT), which may contribute to the effects of oxymetholone. [3] The elimination half-life of oxymetholone is unknown. [2] Oxymetholone and its metabolites are eliminated in the urine . [1] [2]

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