Unlike other anabolic steroids Oxandrolone has two major advantages: First, it does not convert to estrogen which causes gynecomastia . Second, it does not significantly influence the body's normal testosterone production (HPTA axis) at low dosages (10mgs). When dosages are high (this goes for any anabolic steroid) then your body feels that it has enough testosterone and it reduces the production of LH (luteinizing hormone) which no longer stimulates Leyding cells in testicles to produce testosterone therefore causing testicular atrophy (shrinking). Post Cycle Therapy (PCT) is of course needed for high dosages (40–50 mg) of this synthetic derivative of testosterone because as the dosage increases the influence on HPTA is bigger. Lack of PCT will of course lead to protein catabolism until body's normal testosterone secretion is back to normal. Bodybuilders consider a normal dose for a novice 20–30 mg per day, when in fact 10 mg is more than enough for someone who has never used it[unreliable source?]. Higher dosages not only lead to AR (Androgen Receptor) downregulation and HPTA suppression but also damage the liver being a 17?-alkylated steroid. It is specifically made 17?-alkylated because if it weren't the liver would consider it a toxin and destroy Searle stopped production, biggest sellers are La Pharma Italy and British Dragon Thailand.
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